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KMID : 0191120100250101529
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Journal of Korean Medical Science
2010 Volume.25 No. 10 p.1529 ~ p.1531
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Hemophagocytic Syndrome in a Patient with Acute Tubulointerstitial Nephritis Secondary to Hepatitis A Virus Infection
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Cho Eun-Jung
Cha In-Hye
Yoon Ki-Chul
Yang Ha-Na
Kim Hye-Won
Kim Myung-Gyu
Jo Sang-Kyung
Cho Won-Yong
Kim Hyoung-Kyu
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Abstract
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Hepatitis A virus (HAV) infection is generally a self-limited disease, but the infection in adults can be serious, to be often complicated by acute kidney injury (AKI) and rarely by virus-associated hemophagocytic syndrome (VAHS). Our patient, a 48-yr-old man, was diagnosed with HAV infection complicated by dialysis-dependent AKI. His kidney biopsy showed acute tubulointerstitial nephritis with massive infiltration of activated macrophages and T cells, and he progressively demonstrated features of VAHS. With hemodialysis and steroid treatment, he was successfully recovered.
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KEYWORD
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Acute Hepatitis A, Acute Kidney Injury, Lymphohistiocytosis, Hemophagocytic
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